Welcome to The Gould LabWe are interested in how the environment shapes our physiology and metabolism and how this impacts upon health and disease. Research focuses on identifying the protective mechanisms that allow developing and adult animals to cope with environmental challenges such as malnutrition and oxidative stress. This research also aims to shed light on the complex interactions between environmental factors and the genes influencing metabolic and age-related diseases.
Much of our research utilises the fruit fly Drosophila, a model organism that shares many genes with humans and has contributed to our understanding of several different aspects of health and disease. We are also following up some of our most significant Drosophila findings in mammalian models. The lab uses a wide variety of experimental approaches including genetics, confocal microscopy, imaging mass spectrometry and metabolomics.
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Latest newsA postdoctoral research position funded by the Wellcome Trust is now available. More information April 2019: Pany has a collaborative paper with Louise Cheng’s lab on why some neural tumours are more reliant than others on dietary histidine. EMBO J. 2019 April 2019: Thari and Paul have improved our method for measuring absolute metabolite concentrations in tiny samples of unknown volume. J Proteome Res. 2019 |
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