Welcome to The Gould LabWe are interested in how the environment shapes our physiology and metabolism and how this impacts upon health and disease. Research focuses on identifying the protective mechanisms that allow developing and adult animals to cope with environmental challenges such as malnutrition and oxidative stress. This research also aims to shed light on the complex interactions between environmental factors and the genes influencing metabolic and age-related diseases.
Much of our research utilises the fruit fly Drosophila, a model organism that shares many genes with humans and has contributed to our understanding of several different aspects of health and disease. We are also following up some of our most significant Drosophila findings in mammalian models. The lab uses a wide variety of experimental approaches including genetics, confocal microscopy, imaging mass spectrometry and metabolomics.
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Latest newsMay 2021: Ola and Alex contribute to a Crick News Feature on how powerful Drosophila genetics can be used to discover how lipid droplets protect renal and other cells from metabolic stresses May 2021: Ola Lubojemska’s paper now out at PLOS Biology shows how the lipid droplet enzyme ATGL protects Drosophila renal cells from the damaging effects of a high fat diet. May 2021: Launch of the European Drosophila Society A NEW central resource for the European fly community which supports community initiatives and oversees the organisation of the biennial European Drosophila Research Conference. You are all warmly invited to sign up and get your labs on the interactive map at: https://europeandrosophilasociety.org |
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