Welcome to The Gould Lab
We are interested in how the environment shapes our physiology and metabolism and how this impacts upon health and disease. Research focuses on identifying the protective mechanisms that allow developing and adult animals to cope with environmental challenges such as malnutrition and oxidative stress. This research also aims to shed light on the complex interactions between environmental factors and the genes influencing metabolic and age-related diseases.
Much of our research utilises the fruit fly Drosophila, a model organism that shares many genes with humans and has contributed to our understanding of several different aspects of health and disease. We are also following up some of our most significant Drosophila findings in mammalian models. The lab uses a wide variety of experimental approaches including genetics, confocal microscopy, imaging mass spectrometry and metabolomics.
Sept. 2017: More than you needed to know about lipid droplets? A new review by Michael Welte and Alex Gould: Lipid droplet functions beyond energy storage.
Work published in BBA - Molecular and Cell Biology of Lipids (free pdf until 31/10/17)
August 2017: Postle and Gould labs collaborate on new techniques for measuring the dynamics of lipid metabolism using electrospray ionisation mass spectrometry (ESI-MS).
Work published in BBA - Molecular and Cell Biology of Lipids